HKU scientists invent universal antibody drug for HIV-1 prevention, immwristband computerunotherapy

Surviving Your First Music Festival Gig
Taking the stage by storm will be Seattle"s own, THEESatisfaction who are not only in town to celebrate the 1 year anniversary of thier collective, but are also here on their first-ever tour: The Black Weirdo Tour. JON AUER: All you can really hope to do in life it to keep evolving, growing. I"m not religious at all - let me be clear about that - but I kind of like the serenity prayer....y"know, the bits about changing what you can, letting go of what you can"t, and the wisdom to know the difference. Seems like a good philosophy even in a digital age. The Black Weirdo Tour began in Austin, Texas where the group performed for the city"s annual, South By South West festival wristbands. Next on the list was a trip to California where the duo performed two shows. Now they"re here in Toronto for a 3 day performance set. Former Dead Boys guitarist Cheetah event wristbands Chrome aka Gene O"Connor recalls the Cleveland punk scene a bit differently but chalks it up to a brief relocation to New York. For a chance to participate in some good-old-fashioned fun, join the revelry at the Frontier Days Festival. Visitors can enjoy seeing the period clothing and eating period food. The festival also features a carnival, children"s games, and some very unique contests. No Frontier Day festival would be complete without a greased pig catch and nail-driving contest. There will also be several quilts for view as well as a parade sport wristbands on Saturday. Sound daunting? It"s really not. I have good news and great news for you. The good news is that in your day to day life there are many times when you "perform". By performing I"m talking about subtle, but significant behaviors - like changing the tone of your voice; using physical gestures; being verbally descriptive, etc. My experience is that people naturally do this when they are speaking about a topic they feel some emotional connection to. However, when people get up in front of an audience, they often suppress this natural performing ability, mainly because of fear. One other thing: the early bird gets the worm. The WMS has a history of selling out, and prices go up considerably on festival day, anyhow-so be sure to get your wristbands early. Currently, festival wristbands are available for only $20, with VIP passes available for $75. The wristbands are good for any venue, all day. Even without knowing the specific lineup of locals, $20 to see all of them means you"ll definitely get your money"s worth.

HONG KONG - A research team led by scientists of the University of Hong Kong (HKU) announced Thursday the invention of a universal antibody drug against HIV/AIDS that can "kill two birds with one stone."

By engineering a tandem bi-specific broadly neutralizing antibody (bNAb), the team found that this novel antibody drug is universally effective not only against all genetically divergent global HIV-1 strains tested, but also promoting the elimination of latently infected cells in a humanized mouse model, the team announced at a press conference.

The single gene-encoded tandem bNAb titled "BiIA-SG" strategically ambushes invading HIV-1 particles to protect CD4 positive T cells by attaching to host protein CD4. BiIA-SG not only displays a potent activity against all three panels of 124 genetically divergent global HIV-1 strains tested, but also prevents diverse live viral challenges completely in humanized mice.

Moreover, gene transfer of BiIA-SG achieves pro-longed drug availability in vivo, leading to a promising efficacy of eliminating HIV-1 infected cells in humanized mice.

With significantly improved breadth and potency, BiIA-SG will hopefully be the first "made in Hong Kong" anti-HIV-1 antibody drug for clinical development, the team said.

The research team was led by scientists at AIDS Institute and Department of Microbiology of HKU"s Li Ka Shing Faculty of Medicine. The new findings were published in the April issue of Journal of Clinical Investigation, one of the world"s leading biomedical journals.


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